Bateman model: C(t) = A(e-ke·t - e-ka·t) — click chart to set NOW, then add doses
Y-axis: 100% = peak concentration of one full dose taken fasting · therapeutic min ~25%, dyskinesia ~80%
THIS TOOL VISUALIZES — IT DOES NOT PRESCRIBE. It mathematically models the decay of the medication schedule your doctor already prescribed. It does not account for individual physiology, drug interactions, or clinical context. No output is medical advice. Always consult your physician before making any changes to your medication schedule.
2:00 PMNOW — drag on chart to move
Activity Demand — click/drag to paint
Calendar → Demand (demo)
In the real app, this reads your phone's calendar automatically. Here, add events to see how your day's activities shape the demand curve above.
Eating Windows — meals marked PROTEIN reduce levodopa absorption
LOW 0.20 mL/hr · BASE 0.25 · HIGH 0.30 · EXTRA DOSE 0.10 mL · PUMP CYCLE ~20 min
Foslevodopa/foscarbidopa delivered subcutaneously via a wearable infusion pump in discrete ~20-minute pulses — each cycle delivers a tiny SC bolus, summing to a near-flat baseline with visible saw-tooth oscillation at the 90-min systemic levodopa half-life. The chart shows the actual pulse pattern, not a smoothed line. Protein meals still matter: even though SC delivery bypasses the gut, dietary LNAAs (leucine, isoleucine, valine, phenylalanine, tyrosine…) compete with levodopa at the LAT1 transporter on the blood-brain barrier. Plasma stays at the pulse-summed baseline, but effective brain levodopa dips during and after protein meals — many patients on continuous infusion still report slowing down at meal time. The chart shows this as a dip in the baseline during meals marked PROTEIN. Bolus doses you add (manual EXTRA DOSE on the pump) appear as larger Bateman peaks layered on top.
Infusion Baseline — where the infusion saw-tooth sits on the chart
baseline 55%
Personal calibration: where the SC infusion saw-tooth averages on the chart (y-axis units, same scale as everything else). Default 55% — drag lower if your morning routine peaks without dyskinesia suggest your real baseline is lower, higher if you feel close to dyskinesia on pump-only.
Personal BBB Factor — brain levodopa multiplier with food
food 80% · protein 60%
Set how much your effective brain levodopa drops during meals. Default 80% (mild 20% dip with any food). Protein meals automatically double the reduction (LNAAs from protein compete much more strongly than carbs or fat for LAT1 transport).
HALF-LIFE90 min
Tmax45 min
BIOAVAIL (F)0.99
DYSKINESIA TOLERANCE
Dose Log
DOSES TODAY0
CURRENT LEVEL0%
TIME IN RANGE—
NEXT DOSE IN—
VARIABILITY±50%
Expected blood concentration (Bateman equation)
Confidence band (population variability in absorption & elimination)
Therapeutic window (effective range without dyskinesia)
Circadian zones — morning peak (best absorption), afternoon dip (wearing off risk), wind-down
No black box. Every paper and data source behind the pharmacokinetic model is listed here. You see what the math sees — nothing hidden, nothing invented. The source code will be released for independent review.
ANCHOREDThe PK model is pinned to published pharmacokinetic parameters — not a drifting LLM. The math cannot silently change between updates.
ON-DEVICEThe PK model runs on your phone. No cloud. No server. All computation is local.
LOCALYour dose logs and subjective reports stay on your phone by default. Join the fight beyond your own case: opt in to share anonymized, aggregated patterns with researchers — never your identity, never automatic, never without consent. See exactly what gets shared →
TRACEABLEEvery parameter in the Bateman equation traces to a published source below. If it's not in the Glass Box, the model won't use it.
Levodopa IR: t½ 90 min, Tmax 30-60 min, F=99% — from FDA prescribing label + Nutt & Fellman (1984) Levodopa CR: t½ 90 min, Tmax 120 min, F=71% — from FDA prescribing label + Yeh et al. (1989) Levodopa ER (dual-phase): 60% fast / 40% slow, Tmax 1h/4h — from Hauser et al. (2013) + FDA label Foslevodopa/foscarbidopa SC infusion: continuous wearable pump, ~20-min cycles, F≈100% (subcutaneous, bypasses first-pass) — from prescribing info (citation #07) Food effect: high-protein meals delay Tmax by ~30 min, reduce Cmax — from competitive amino acid transport literature
GLASS_BOX_POLICY: Every parameter in this simulation traces to a published pharmacokinetic source. The Bateman equation is the standard one-compartment oral absorption model used in clinical pharmacology. No proprietary algorithms. No hidden tuning. No synthetic data.
