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Biomarker Activity Over Fast Duration
Estimated relative activity levels (0–120 hours) — hover for details, click legend to toggle
0h Not fasting
0h 24h 48h 72h 96h 120h
Optimal window (24–72h)
Diminishing returns (72–100h)
Danger — medical refeeding (100–120h+)
Glass Box // what the AI reads

No black box. Every paper our model ingests is listed here. You see what the AI sees — nothing hidden, nothing hallucinated. This is the foundation the engine runs on. The source code will be released for independent review.

ANCHORED The AI is pinned to static, versioned data — not a drifting LLM. The science cannot silently change between updates.
ON-DEVICE The AI model lives on your phone. No cloud. No server. All inference runs locally.
LOCAL Your data stays on your phone by default. Join the fight beyond your own case: opt in to share anonymized, aggregated patterns with researchers — never your identity, never automatic, never without consent. See exactly what gets shared →
TRACEABLE Every claim the AI makes cites a specific paper below. If it's not in the Glass Box, the AI won't say it.
Foundational Papers
01 Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial Phillips et al. — Movement Disorders, 2018
02 Mitophagy in the pathogenesis and management of disease Nature Cell Research, 2025
03 Canonical and noncanonical autophagy: involvement in Parkinson's disease Frontiers in Cell and Developmental Biology, 2025
04 The role of autophagy in Parkinson's disease Haghighirad, B.
Supplementary Research
05 The promise of GLP-1 receptor agonists for neurodegenerative diseases Journal of Clinical Investigation
06 Autophagic stress activates distinct compensatory secretory pathways in neurons Palumbos et al. — PNAS, 2025
07 Autophagy and Cellular Senescence in Alzheimer's Disease: Key Drivers of Neurodegeneration CNS Neuroscience & Therapeutics, 2025
08 Secretory autophagy Current Opinion in Cell Biology, 2015
09 Immunologic manifestations of autophagy Journal of Clinical Investigation
10 Precision autophagy directed by receptor regulators — emerging examples within the TRIM family Journal of Cell Science, 2017
11 Macroautophagy: degradation of intracytoplasmic contents including proteins and organelles Journal of Experimental Medicine, 2015
12 Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation Nature Communications, 2022
13 Gut Microbiota in Autophagy Regulation: New Therapeutic Perspective in Neurodegeneration Life, 2023
14 Global trends and perspectives in mitophagy on neurodegenerative diseases: a scientometric analysis Frontiers in Medicine, 2025
15 Development and Synthesis of Biologically Active Compounds International Journal of Molecular Sciences, 2024
The Foundational 60

15 researchers × 4 papers each — Breakthrough, Mechanism, Proof, Synthesis. Structured to prevent cherry-picking and ensure full evolutionary logic of each researcher's contribution. PENDING INGESTION

1. Biological Bedrock
Ana Maria Cuervo, MD, PhD — Chaperone-Mediated Autophagy
2. Neuro-Defense Track
Ray Dorsey, MD — Neuro-Strategy
P3Dorsey et al. — Ending Parkinson's Disease. PublicAffairs, 2020
Matthew Phillips, MD — Clinical Fasting/PD
3. Molecular Logic
Isabella Cooper, PhD — Metabolic Gears
P4Cooper — Reframing the glucose-insulin-glucagon axis. Nature Metabolism Review, 2022
Toshia Myers, PhD — The Toggle
P1Myers — IF and Inflammation: reducing visceral fat and CRP. J Nutritional Science, 2017
P2Myers — Epigenetic modifications induced by fasting and CR. Epigenomics, 2019
P3Myers & Goldhamer — Clinical Safety of Water-Only Fasting: 10-year retrospective. J Clinical Medicine, 2022
P4Myers — Ketogenic Diets and IF in Neurologic Diseases. J Endocrinology and Metabolism, 2021
Steven R. Gundry, MD — Uncoupling
P2Gundry — Dietary Intervention with a Plant-Based, Low-Lectin Diet. J Clinical Medicine, 2018
P3Gundry — The Longevity Paradox. Harper Wave, 2019
P4Gundry — Unlocking the Keto Code. Harper Wave, 2022
4. Systemic Safety
Bret Scher, MD, FACC — The Heart
P1Scher — Lifestyle medicine: first line of defense against CVD. American J Cardiology, 2019
P2Scher — Therapeutic Carbohydrate Restriction for CV Health. J Metabolic Health, 2020
P3Scher — Ketone levels and Mental Health. J Psychiatry and Neuroscience, 2021
P4Scher — Lipidology in the Low-Carb Context. J Clinical Lipidology, 2022
Stephen Cunnane, PhD — The Fuel
P1Cunnane et al. — PET Imaging of Brain Ketone Uptake. J Cerebral Blood Flow & Metabolism, 2011
P2Cunnane et al. — Can Ketones Help Rescue Brain Fuel Supply? Applied Physiology, Nutrition, and Metabolism, 2016
Alan Goldhamer, D.C. — Deep Clearance
P3Goldhamer et al. — Safety of water-only fasting: 2000 patients. J Complementary and Integrative Medicine, 2015
P4Goldhamer — Fasting impact on human proteome and biological age. Nature Communications, 2024
5. Metabolic Therapy
GLASS_BOX_POLICY: This list updates as new papers enter the knowledge base. 82 papers targeted at launch (15 ingested, 67 pending). Every claim the AI makes traces back to one of these sources. No synthetic data. No unattributed inference.